Month: January 2022

Authors Gach-Janczak, K; Drogosz-Stachowicz, J; Dlugosz-Pokorska, A; Jakubowski, R; Janecki, T; Szymanski, J; Janecka, A in MDPI published article about CANCER-CELLS; DNA-DAMAGE; IN-VITRO; SESQUITERPENE LACTONE; KAPPA-B; PARTHENOLIDE; COMBINATION; PACLITAXEL; AGENTS; MITOCHONDRIA in [Gach-Janczak, Katarzyna; Drogosz-Stachowicz, Joanna; Dlugosz-Pokorska, Angelika; Janecka, Anna] Med Univ Lodz, Dept Biomol Chem, Mazowiecka 6-8, PL-92215 Lodz, Poland; [Jakubowski, Rafal; Janecki, Tomasz] Lodz Univ Technol, Inst Organ Chem, Zeromskiego 116, PL-90924 Lodz, Poland; [Jakubowski, Rafal] Polish Acad Sci, Ctr Mol & Macromol Studies, Sienkiewicza 112, PL-90363 Lodz, Poland; [Szymanski, Jacek] Med Univ Lodz, Cent Lab, Mazowiecka 6-8, PL-92215 Lodz, Poland in 2020.0, Cited 62.0. Name: 1,1,1-Triethoxyethane. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7

In the search for new drug candidates, researchers turn to natural substances isolated from plants which may be either used directly or may serve as a source for chemical modifications. An interesting strategy in the design of novel anticancer agents is based on the conjugation of two or more biologically active structural motifs into one hybrid compound. In this study, we investigated the anticancer potential of 4-benzyl-5,7-dimethoxy-4-methyl-3-methylidene-3,4-dihydro-2H-chroman-2-one (DL-247), a new hybrid molecule combining a chroman-2-one skeleton with an exo-methylidene bond conjugated with a carbonyl group, in human myeloid leukemia HL-60 cell line. The cytotoxicity of the new compound was tested using MTT assay. The effect of DL-247 on cell proliferation and apoptosis induction were studied by flow cytometry, fluorometric assay and ELISA analysis. DL-247 displayed high cytotoxic activity (IC50 = 1.15 mu M, after 24 h incubation), significantly inhibited cell proliferation and induced apoptosis by both, the intrinsic and extrinsic pathways. A combination of DL-247 with taxol exhibited a strong synergistic effect on DNA damage generation, apoptosis induction and inhibition of cell growth.

Name: 1,1,1-Triethoxyethane. Bye, fridends, I hope you can learn more about C8H18O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Synthesis and biological activity of new derivatives with the preserved carane system published in 2020.0. Computed Properties of C8H18O3, Reprint Addresses Koziol, A (corresponding author), Wroclaw Univ Sci & Technol, Fac Chem, Dept Bioorgan Chem, Wroclaw, Poland.; Koziol, A (corresponding author), Acad Physiotherapy Wroclaw, Inst Cosmetol, Wroclaw, Poland.. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane

Terpenoid derivatives, which contain a preserved carane system in their structure, exhibit a broad spectrum of biological activities. Among them, we can distinguish insecticides, structures with pharmacological application etc. In the presented paper, the substrate – (-)-cis-caran-trans-4-ol was transformed using the reactions of typical organic synthesis to obtain novel derivatives. Most importantly, bromolactone ((-)-(1R,4R,6S)-2′-(bromomethyl)-4,7,7-trimethylspiro[bicyclo[4.1.0]heptan-3,3′-furan]-5′(4’H)-one) with the preserved carane system was synthesized. This bromolactone was tested for antifeedant activity against the lesser mealworm, Alphitobius diaperinus Panzer, and peach potato aphid (Myzus persicae). In addition, its moderate antibacterial activity was observed against the Bacillus subtilis strain (with Minimal Inhibitory Concentration of 200 mu g/mL).

Computed Properties of C8H18O3. Welcome to talk about 78-39-7, If you have any questions, you can contact Koziol, A; Fratczak, J; Grela, E; Szczepanik, M; Gabrys, B; Dancewicz, K; Lochynski, S or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Computed Properties of C15H12O. In 2021.0 MOLECULES published article about TIME-OF-FLIGHT; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY in [Cortes-Chitala, Maria del Carmen; Flores-Martinez, Hector; Leon-Campos, Carolina; Lopez-Muraira, Irma] TecNM ITTlajomulco, Km 10 Carretera Tlajomulco San Miguel Cuyutlan, Tlajomulco De Zuniga 45640, Jalisco, Mexico; [Orozco-Avila, Ignacio; Estarron-Espinosa, Mirna] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Tecnol Alimentaria, AC Camino Arenero 1227, Zapopan 45019, Jalisco, Mexico; [Suarez-Jacobo, Angela] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Biotecnol Ind, AC Camino Arenero 1227, Zapopan 45019, Jalisco, Mexico in 2021.0, Cited 49.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Plants have been used for thousands of years for various purposes because they have a wide variety of activities with biological significance. Mexican oregano is an aromatic plant of great importance to Mexico and north of Jalisco state as a spice with important economic value. Chromatographic identification and quantification of phenolic compounds and evaluation of their antioxidant activity were important tools to obtain a better characterization of this spice. Phytochemical analysis indicated the presence of flavonoids, triterpenes, saponins, quinones and tannins, the latter at high concentrations. Through chromatographic assays of Mexican oregano extracts, 62 compounds were identified, the major ones being quantified as: taxifolin, apigenin 7-O-glucoside, phlorizin, eriodictyol, quercetin, naringenin, hispidulin, pinocembrin, galangin and genkwanin (compound for the first time reported for this species). The results can be useful as a precedent to establish the bases of new quality characterization parameters and they have also suggested that Mexican oregano contains a wide variety of compounds with untapped importance for the development of new high value-added products.

Computed Properties of C15H12O. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Effect of substituents in the A and B rings of chalcones on antiparasite activity published in 2020.0. Computed Properties of C15H12O, Reprint Addresses Quinones, W (corresponding author), Univ Antioquia, Inst Quim, Fac Ciencias Exactas & Nat, Grp Quim Organ Prod Nat QOPN, Calle 70 52-21, Medellin 1226, Colombia.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

Chalcones are a group of natural products with many recognized biological activities, including antiparasitic activity. Although a lot of chalcones have been synthetized and assayed against parasites, the number of structural features known to be involved in this biological property is small. Thus, in the present study, 21 chalcones were synthesized to determine the effect of substituents in the A and B rings on the activity againstLeishmania braziliensis, Trypanosoma cruzi, andPlasmodium falciparum. The compounds were active againstL. braziliensisin a structure-dependent manner. Only one compound was very active againstT. cruzi, but none of them had a significant antiplasmodial activity. The electron-donating substituents in ring B and the hydrogen bonds at C-2 ‘ with carbonyl affect the antiparasitic activity.

Welcome to talk about 94-41-7, If you have any questions, you can contact Gonzalez, LA; Upegui, YA; Rivas, L; Echeverri, F; Escobar, G; Robledo, SM; Quinones, W or send Email.. Computed Properties of C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Computed Properties of C15H12O. In 2020.0 INORG CHEM published article about LIGHT PHOTOREDOX CATALYSIS; TRANSFER EXCITED-STATES; SENSITIZED SOLAR-CELLS; CARBENE COMPLEX; METAL-COMPLEXES; LUMINESCENCE; DYNAMICS; PROGRESS; REDOX; YIELD in [Zhang, Yu; Leary, Dylan C.; Belldina, Anne M.; Petersen, Jeffrey L.; Milsmann, Carsten] West Virginia Univ WVU, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA in 2020.0, Cited 62.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

A series of seven bis(pyridinedipyrrolide)zirconium complexes, Zr((PDPR2)-P-R1)(2), where [(PDPR2)-P-R1](2-) is the doubly deprotonated form of [2,6-bis(5-R-1-3-R-2-1H-pyrrol-2-yl)pyridine], were prepared and characterized in solution by NMR, UV/vis absorption, and emission spectroscopy and cyclic voltammetry. The molecular structures were determined by single-crystal X-ray crystallography. All complexes exhibit remarkably long emission lifetimes (tau = 190-576 mu s) with high quantum efficiencies (Phi(PL) = 0.10-0.38) upon excitation with visible light in a benzene solution. The substituents on the pyrrolide rings were shown to have significant effects on the photoluminescence and electrochemical properties of these compounds. The R-2 substituents (R-2 = H, Me, Ph, or C6F5) show only limited effects on the absorption and emission profiles of the complexes but allow systematic tuning of the ground- and excited-state redox potentials over a range of almost 600 mV. The R-1 substituents (R-1 = H, Me, Ph, or 2,4,6-Me3Ph) influence both the optical and electrochemical properties through electronic effects. Additionally, the R-1 substituents have profound consequences for the structural flexibility and overall stability of the compounds. Distortions of the Zr(PDP)(2) core from idealized D-2d symmetry in the solid state can be traced to the steric profiles of the R-1 substituents and correlate with the observed Stokes shifts for each compound. The complex with the smallest ligand system, Zr((PDPH)-P-H)(2), coordinates two additional solvent molecules in a tetrahydrofuran (THF) solution, which allowed the isolation of photoluminescent, eight-coordinate Zr((PDPH)-P-H)(2) (THF)(2). The photoredox catalytic dehalogenation of aryl iodides and aryl chlorides using the most reducing derivative, Zr((PDPMe)-P-Me)(2), highlights the potential of Zr(PDP)(2) photosensitizers to promote challenging reductive transformations under mild conditions upon excitation with green light.

Welcome to talk about 94-41-7, If you have any questions, you can contact Zhang, Y; Leary, DC; Belldina, AM; Petersen, JL; Milsmann, C or send Email.. Computed Properties of C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Radical C-N Borylation of Aromatic Amines Enabled by a Pyrylium Reagent WOS:000521630700012 published article about CARBON-NITROGEN BONDS; METAL-FREE BORYLATION; CROSS-COUPLINGS; NUCLEOPHILIC DISPLACEMENTS; ANILINE DERIVATIVES; CATALYZED CLEAVAGE; ORGANIC-SYNTHESIS; PYRIDINIUM SALTS; ROOM-TEMPERATURE; BENZYLIC AMINES in [Ma, Yuanhong; Pang, Yue; Niski, Jan; Leutzsch, Markus; Cornella, Josep] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany; [Chabbra, Sonia; Reijerse, Edward J.; Schnegg, Alexander] Max Planck Inst Chem Energiekonvers, Stiftstr 34-36, D-45470 Mulheim, Germany in 2020.0, Cited 110.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Name: Chalcone

Herein, we report a radical borylation of aromatic amines through a homolytic C(sp(2))-N bond cleavage. This method capitalizes on a simple and mild activation via a pyrylium reagent ((Sc)Pyry-OTf) thus priming the amino group for reactivity. The combination of terpyridine and a diboron reagent triggers a radical reaction which cleaves the C(sp(2))-N bond and forges a new C(sp(2))-B bond. The unique non-planar structure of the pyridinium intermediate, provides the necessary driving force for the aryl radical formation. The method permits borylation of a wide variety of aromatic amines indistinctively of the electronic environment.

Name: Chalcone. Welcome to talk about 94-41-7, If you have any questions, you can contact Ma, YH; Pang, Y; Chabbra, S; Reijerse, EJ; Schnegg, A; Niski, J; Leutzsch, M; Cornella, J or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

SDS of cas: 94-41-7. In 2019.0 INT J BIOL MACROMOL published article about NANOPARTICLES; N-2-ARYL-SUBSTITUTED-1,2,3-TRIAZOLES; PYRIMIDINE; CHALCONES; CATALYST; COMPLEX; HPLC in [Khalil, Khaled D.] Taibah Univ, Dept Chem, Fac Sci, Yanbu 46423, Saudi Arabia; [Riyadh, Sayed M.; Ali, Imran] Taibah Univ, Dept Chem, Fac Sci, Al Madinah Al Munawarah 30002, Saudi Arabia; [Khalil, Khaled D.; Riyadh, Sayed M.; Gomha, Sobhi M.] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt; [Gomha, Sobhi M.] Islamic Univ Almadinah Almonawara, Fac Sci, Dept Chem, Almadinah Almonawara 42351, Saudi Arabia; [Ali, Imran] Cent Univ, Jamia Millia Islamia, Dept Chem, New Delhi, India in 2019.0, Cited 44.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Chitosan copper (II) oxide nanocomposite was synthesized, characterized and used to synthesize [1,2,3] triazoles. Nanocomposite was characterized by using FTIR, XRD, FESEM, and EDS techniques, which reflected rough morphology. The powerful catalytic activity of hybrid nanocomposite was utilized to synthesize chalcones (3a-p) in relatively high yields (82%-98%) and multicomponent regio-selective cycloaddition of chalones, aryl halides (4), and sodium azide to afford the expected N-2-aryl[1,2,3]triazoles (5a-h) (80%-95% yield) rather than N-1-aryl(1,2,3]-triazoles (6a-h). The performance of nanomaterial was optimized by several variables. The capability of the nanocomposite was compared with previous work and the nanocomposite was found more efficient, economic and reproducible. The hybrid nanocomposite could be easily isolated form the reaction mixture and recycled four times without any significant loss of its catalytic activity. The reported catalyst is an inexpensive for good yields of the triazoles and may be used at industrial production for the reported compounds. (C) 2019 Published by Elsevier B.V.

SDS of cas: 94-41-7. About Chalcone, If you have any questions, you can contact Khalil, KD; Riyadh, SM; Gomha, SM; Ali, I or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents WOS:000456762500041 published article about ANTIOPPORTUNISTIC INFECTION AGENTS; STAUROSPORINE-INDUCED APOPTOSIS; PHASE-II; HEPATOCELLULAR-CARCINOMA; BIOLOGICAL EVALUATION; DERIVATIVES; MECHANISM; CELLS; TARGET in [Han, Xue; Xiao, Bei-Bei; Cao, Sheng-Li; Yang, Chao-Rui; Wang, Wen-Zhu; Wang, Fu-Cheng; Li, Hong-Yun; Yuan, Xiao-Li] Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China; [Han, Xue; Xiao, Bei-Bei; Cao, Sheng-Li; Yang, Chao-Rui; Wang, Wen-Zhu; Wang, Fu-Cheng; Li, Hong-Yun; Yuan, Xiao-Li; Liao, Ji; Wang, Hailong; Li, Jing] Capital Normal Univ, Beijing Key Lab DNA Damage Response, Beijing 100048, Peoples R China; [Peng, Bin; Shi, Ruifeng; Xu, Xingzhi] Shenzhen Univ, Sch Med, Shenzhen 518060, Guangdong, Peoples R China; [Peng, Bin; Shi, Ruifeng; Xu, Xingzhi] Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Guangdong, Peoples R China; [Liao, Ji; Wang, Hailong; Li, Jing] Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China in 2019.0, Cited 40.0. Name: 1,1,1-Triethoxyethane. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7

The chalcone motif can be found in many molecules that contribute to essential biological processes, and many chalcone-containing compounds exhibit potent anti-cancer activity. Here, we synthesized two series of chalcone analogues (3a-s and 6a-s) based on substituting the chalcone B-ring or A-ring with a 4-oxoquinazolin-2-yl group, and then evaluated them for cytotoxic activity in human colorectal HCT-116 and breast cancer MCF-7 cell lines. Compounds 3a-s (in which a 4-oxoquinazolin-2-yl group functioned as the B-ring) were markedly more cytotoxic than compounds 6a-s (in which 4-oxoquinazolin-2-yl group functioned as the A-ring), based on their IC50 values to inhibit proliferation. Compound 3f was found as the most potent among 38 analogues and the mechanism of its cytotoxicity was investigated. Flow cytometry indicated that HCT-116 cells treated with compound 3f resulted in a dose-dependent accumulation of cells in the sub-G1 phase, which is representative of apoptotic cells. Subsequent assays (including Annexin V-FITC/PI, AO-EB, MitoSOX (TM) Red and JC-1 staining) confirmed that 3f exposure induced apoptosis in HCT-116 cells. Immunoblotting analysis indicated that cellular exposure to 3f increased the cleavage of PARP1 and caspases 3, 7, and 9. Taken together, this novel chalcone analogue has a cytotoxic effect on cultured cancer cell-lines that is likely mediated by inducing apoptosis via the mitochondrial death pathway. (C) 2018 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 78-39-7, If you have any questions, you can contact Han, X; Peng, B; Xiao, BB; Cao, SL; Yang, CR; Wang, WZ; Wang, FC; Li, HY; Yuan, XL; Shi, RF; Liao, J; Wang, HL; Li, J; Xu, XZ or send Email.. Name: 1,1,1-Triethoxyethane

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Convenient one-pot access to 2H-3-nitrothiochromenes from 2-bromobenzaldehydes, sodium sulfide and beta-nitrostyrenes WOS:000474089200006 published article about ENANTIOSELECTIVE SYNTHESIS; THIOCHROMENES; ANALOGS; DESIGN in [Thi Thu Huong Le; Youhei, Chitose; Quy Hien Le; Dinh Hung Mac] VNU Univ Sci, Fac Chem, Med Chem Lab, 19 Le Thanh Thng, Hanoi, Vietnam; [Youhei, Chitose] Hiroshima Univ, Grad Sch Sci, Dept Chem, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 7398526, Japan; [Thanh Binh Nguyen] Univ Paris Saclay, Univ Paris Sud, Inst Chim Subst Nat, CNRS UPR 2301, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France in 2019.0, Cited 29.0. SDS of cas: 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

An efficient synthesis of 2H-3-nitrothiochromenes via a cascade reaction was established. Starting from commercially available o-bromobenzaldehydes and beta-nitrostyrenes with sodium sulfide nonahydrate as an inexpensive sulfur source, various substituted thiochromenes were synthesized with high functional group tolerance without any added transition metal catalyst or additive.

SDS of cas: 94-41-7. Welcome to talk about 94-41-7, If you have any questions, you can contact Le, TTH; Youhei, C; Le, QH; Nguyen, TB; Mac, DH or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Synthesis and properties of gem-dinitro energetic salts based on 1,2,4-oxadiazole with low impact sensitivity WOS:000609189100004 published article about HIGH-NITROGEN; DERIVATIVES; EXPLOSIVES in [Lu, Tian; He, Yuna; Song, Jia; Hou, Zhengwen; Yin, Hongquan; Chen, Fu-Xue] Beijing Inst Technol, Sch Chem Sc Chem Engn, Liangxiang Campus,8 Liangxiang East Rd, Beijing 102488, Peoples R China; [Fan, Guijuan] CAEP, Inst Chem Mat, Mianyang 621050, Sichuan, Peoples R China in 2021.0, Cited 37.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7. Recommanded Product: 1,1,1-Triethoxyethane

Eight energetic salts with a gem-dinitro group based on 1,2,4-oxadiazole were developed. All of the structures were confirmed by infrared (IR) spectroscopy, H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HRMS), and single-crystal X-ray diffraction was used to determine the structures of the pivotal intermediate 3-(chlorodinitromethyl)-5-methyl-1,2,4-oxadiazole (3), the potassium salt (4) and the hydrazinium salt (7). All of them are insensitive to impact (>40 J) and have higher energy levels than trinitrotoluene (TNT).

Recommanded Product: 1,1,1-Triethoxyethane. Welcome to talk about 78-39-7, If you have any questions, you can contact Lu, T; He, YN; Song, J; Hou, ZW; Yin, HQ; Fan, GJ; Chen, FX or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com