Month: September 2021

Recently I am researching about CROSS-ALDOL REACTION; BAYLIS-HILLMAN REACTION; REGIOSELECTIVE SYNTHESIS; ALDEHYDES; REACTIVITY; SILYLENE; ALKYNES; IDENTIFICATION; COORDINATION; INHIBITORS, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP15H05848, JP18H01977, JP18K19079, JP18K14201]; JSPSMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [19J10386]; Iketani Science and Technology Foundation. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Minami, Y; Konishi, A; Yasuda, M. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Recommanded Product: 94-41-7

The synthesis of alpha-alkenyl alpha,beta-unsaturated ketones using germanium(II) salts is reported. Oxagermacycles derived from alpha,beta-unsaturated ketones with germanium(II) salts and aldehydes can be transformed into a-alkenyl a 6-unsaturated ketones. Ammonium salts promoted the elimination of Ge(II) species to afford the two classes of alpha-alkenyl alpha,beta-unsaturated ketones in good yields. The alpha-alkenyl alpha,beta-unsaturated ketones are precursors for multisubstituted heterocycles.

Recommanded Product: 94-41-7. About Chalcone, If you have any questions, you can contact Minami, Y; Konishi, A; Yasuda, M or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recently I am researching about SULFA-MICHAEL ADDITION; ALKYL THIOLS; COMPLEXES; GUANIDINES; DESIGN; ESTERS; CARBON, Saw an article supported by the JSPSMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [16H06354, 16K05680]; Toyota Physical and Chemical Research InstituteToyota Physical and Chemical Research Institute. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Kondoh, A; Ishikawa, S; Terada, M. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Quality Control of Chalcone

Recently, chiral Bronsted bases having high basicity have emerged as a powerful tool in developing new catalytic enantioselective reactions. However, such chiral strong Bronsted base catalysts are still very scarce. Herein, we report the development of a chiral anionic Brensted base having a N,N’-dialkyl ureate moiety as a basic site. Its prominent catalytic activity was demonstrated in the enantioselective addition reactions of alpha-thioacetamides as less acidic pronucleophiles with various electrophiles. Thus, the newly developed chiral catalyst with high accessibility and structural tunability would expand the scope of viable enantioselective transformations under Bronsted base catalysis.

Quality Control of Chalcone. About Chalcone, If you have any questions, you can contact Kondoh, A; Ishikawa, S; Terada, M or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Noble-metal-free TiO2 photocatalysis for selective C = C reduction of alpha,beta-enones by CF3SO3H modification WOS:000556422000002 published article about CHEMOSELECTIVE HYDROGENATION; CONJUGATE REDUCTION; ALCOHOLS; OXIDATION; CATALYSIS; TITANIUM; ELECTRON in [Li, Jundan; Wang, Yi; Zhai, Shan; Ma, Dongge] Beijing Technol & Business Univ, Coll Chem & Mat Engn, Dept Chem, Beijing 100048, Peoples R China; [Liu, Anan] Univ Sci & Technol Beijing, Basic Expt Ctr Nat Sci, Beijing, Peoples R China; [Chen, Chuncheng] Chinese Acad Sci, Inst Chem, Key Lab Photochem, Beijing Natl Lab Mol Sci, Beijing, Peoples R China in 2020.0, Cited 26.0. Category: thiazolidines. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The highly selective C = C reduction of alpha,beta-enones was realized by CF3SO3H-modifying noble-metal-free TiO2 photocatalysis. Selectivity for C = C over C = O reduction was dramatically reversed from fair (similar to 42% without CF3SO3H-modifying) to excellent (> 99%) upon only 6 mol% CF3SO3H loading without any noble-metal additive. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) and C-13-nuclear magnetic resonance (NMR) demonstrated that CF3SO3H modification results in the alpha,beta-enone polar C = O bond sitting away from rather than near to the active sites of polar TiO2 catalysts.

Category: thiazolidines. About Chalcone, If you have any questions, you can contact Li, JD; Liu, AN; Wang, Y; Zhai, S; Ma, DG; Chen, CC or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Total synthesis of (+)-gamma-lycorane from ethyl lactate using iterative Claisen and Overman rearrangement reactions published in 2020.0. Formula: C8H18O3, Reprint Addresses Prasad, KR (corresponding author), Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India.. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane

Total synthesis of (+)-gamma-lycorane is accomplished from (S)-ethyl lactate. Key disconnections in the synthesis involve an iterative Claisen and Overman rearrangement reactions to install the chiral centers in the tetrahydroindole moiety while, Pictet-Spengler reaction is used for the synthesis of the isoquinoline unit. (C) 2020 Elsevier Ltd. All rights reserved.

Formula: C8H18O3. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Uphade, MB; Prasad, KR or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Name: Chalcone. In 2020.0 J ORG CHEM published article about ONE-POT SYNTHESIS; AMINATION; FLUORINE; INDOLES in [Xu, Yumin; Chen, Xiaoqian; Gao, Yiqin; Wan, Changfeng; Liu, Jin-Biao] Jiangxi Normal Univ, Coll Chem & Chem Engn, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China; [Xu, Yumin; Chen, Xiaoqian; Gao, Yiqin; Wan, Changfeng; Liu, Jin-Biao] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China; [Liu, Jin-Biao] Jiangxi Univ Sci & Technol, Sch Met & Chem Engn, Ganzhou 341000, Peoples R China; [Yan, Zicong; Wang, Zhiyong] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China in 2020.0, Cited 47.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

An efficient approach to prepare trifluoromethyl-alpha-carbolines and ester group-substituted alpha-carbolines via the tandem cyclization reaction of 2-(2-aminophenyl)acetonitriles and trifluoromethyl 1,3-diones or beta,gamma-unsaturated alpha-ketoesters was reported. The transformation proceeded smoothly in the presence of catalytic environmental-benign iron salts, which are used to prepare the desired products in moderate to good yields.

Name: Chalcone. About Chalcone, If you have any questions, you can contact Xu, YM; Chen, XQ; Gao, YQ; Yan, ZC; Wan, CF; Liu, JB; Wang, ZY or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Cascade cyclization versus chemoselective reduction: a solvent-controlled product divergence published in 2020.0. HPLC of Formula: C15H12O, Reprint Addresses Jafarpour, F (corresponding author), Univ Tehran, Sch Chem, Coll Sci, Tehran 141556455, Iran.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

A simple and efficient strategy for the assembly of polysubstituted thiophenes and the chemoselective reduction of alpha,beta-unsaturated ketones via the reaction of enones with elemental sulfur and by a simple switching of the reaction solvent is described. Mechanistic studies revealed that both the reactions proceeded via radical pathways, and two hydrogen atoms came from H2O in the reduction course.

HPLC of Formula: C15H12O. About Chalcone, If you have any questions, you can contact Jafarpour, F; Rajai-Daryasarei, S; Gohari, MH or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article A highly efficient Hg(OTf)(2)-mediated Sakurai-Hosomi allylation of N-tert-butyloxycarbonylamino sulfones, aldehydes, fluoroalkyl ketones and alpha,beta-unsaturated enones using allyltrimethylsilane WOS:000501342100012 published article about CATALYTIC ENANTIOSELECTIVE ADDITION; ASYMMETRIC ALLYLATION; MEDIATED CYCLIZATION; CONJUGATE ALLYLATION; HOMOALLYLIC AMINES; AROMATIC-ALDEHYDES; CARBONYL-COMPOUNDS; GALLIUM CHLORIDE; ALLYLSILANES; MERCURY in [Gong, Yi; Zhou, Ying; Zhou, Jian] Guiyang Univ Chinese Med, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China; [Cao, Zhong-Yan; Zhou, Feng; Zhou, Jian] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, 3663N Zhongshan Rd, Shanghai 200062, Peoples R China; [Cao, Zhong-Yan] Zhejiang Univ Technol, Coll Chem Engn, Chaowang Rd 18, Hangzhou 310014, Zhejiang, Peoples R China; [Shi, Ying-Bo] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610066, Sichuan, Peoples R China; [Zhou, Jian] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2019.0, Cited 86.0. Recommanded Product: Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

It is reported that cheap and easily available Hg(OTf)(2) can efficiently mediate the Sakurai-Hosomi reaction of N-tert-butyloxycarbonyl (Boc) amino sulfones, aldehydes, and alpha-fluoroalkyl ketones using allyltrimethylsilane, with the catalyst loading down to 0.5-5.0 mol%, enabling the facile access to synthetically valuable homoallylic alcohols or amines, respectively. A chemoselective 1,4-allylation of alpha,beta-unsaturated enones is also achieved under the catalysis of 5.0 mol% Hg(OTf)(2). In most cases, Hg(OTf)(2) exhibited intriguing properties superior to those of commonly used metal Lewis acids for such reactions, suggesting that mercury catalysis is worthwhile to explore.

About Chalcone, If you have any questions, you can contact Gong, Y; Cao, ZY; Shi, YB; Zhou, F; Zhou, Y; Zhou, J or concate me.. Recommanded Product: Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: 94-41-7. I found the field of Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine very interesting. Saw the article TianJiu therapy for alpha-naphthyl isothiocyanate-induced intrahepatic cholestasis in rats treated with fresh Ranunculus sceleratus L. published in 2020.0, Reprint Addresses Cheng, WM; Zhang, QL (corresponding author), Anhui Med Univ, Sch Pharm, Hefei 230032, Anhui, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone.

Ethnopharmacological relevance: TianJiu (TJ) therapy, one type of cold moxibustion, applies to specific acupuncture points with herbal patches of hot nature, providing a constant irritant to the skin until the presence of hyperemia and blistering. Traditional and clinical reports suggest that TJ is an effective therapy for the treatment of jaundice with fresh Ranunculus sceleratus L. (RS), in which protoanemonin is one of the main irritant constituents. However, the therapeutic effect of TJ treatment with fresh RS against intrahepatic cholestasis has not been studied in animal experiments. Aim of the study: Present study was undertaken to investigate the effect of TJ treatment with fresh RS against intrahepatic cholestasis in rats and provide an experimental basis for the underlying mechanism of TJ therapy. Materials and methods: Male intrahepatic cholestatic Sprague-Dawley rats induced by 2% alpha-naphthylisothiocyanate (ANIT, 80 mg/kg B.W.) were treated by TJ therapy with fresh RS. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), direct bilirubin (DBIL), total bilirubin (TBIL), total bile acid (TBA), hepatic malondialdehyde (MDA) and nitric monoxide (NO), as well as hepatic body ratio, bile flow and hepatic histopathological assay were measured and evaluated to investigate the therapeutic effect of TJ treatment with fresh RS. Phytochemical analysis of fresh and dried RS was performed by gas chromatography-mass spectrometer (GC-MS). Results: After TJ treatment with fresh RS, the abnormally elevated levels of serum AST, ALT, ALP, DBIL, TBIL and TBA, as well as hepatic MDA and NO at 108 h were reduced significantly (versus model group, P < 0.01). The hepatic body ratio, bile flow and hepatic pathological change of cholestatic rats at 108 h in TJ group were restored when compared with those of model group. Thirty-one compounds including lactones, flavonoids and phenolic acids were identified and determined by GC-MS analysis. The content of protoanemonin in fresh RS (9.49%) was about 25-fold higher than that in dried RS (0.38%). Conclusions: TJ treatment with fresh RS exhibited good therapeutic effect on ANIT-induced intrahepatic cholestasis in rats, which may be due to the attenuated oxidative stress in the liver tissue. It is rational for the ancients to choose fresh RS as TJ herbal patches because of its abundant protoanemonin with the character of irritant. The qualitative and quantitative results of GC-MS analysis provided the chemical basis of TJ therapy with fresh RS, which can be regarded as a simple and efficient method for the treatment of cholestasis hepatitis. About Chalcone, If you have any questions, you can contact Zhang, ZY; Miao, YR; Xu, M; Cheng, WM; Yang, CY; She, XJ; Geng, QQ; Zhang, QL or concate me.. Recommanded Product: 94-41-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Sun, HY; Wu, GM; Xie, XG in [Sun, Haiyu; Wu, Guangmiao; Xie, Xingang] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China published Synthetic studies towards daphniyunnine B: Construction of AC bicyclic skeleton with two vicinal all carbon quaternary stereocenters in 2019.0, Cited 32.0. Name: 1,1,1-Triethoxyethane. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

The AC bicyclic skeleton of daphniyunnine B with the required 3. stereocenters (C4, C5 and C8) was accomplished in a concise route which featured two Claisen-type rearrangement reactions to construct the required vicinal all carbon quaternary stereocenters (C5 and C8) and an intramolecular iodocyclization reaction to assemble the cis-confused bicyclic lactam. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Name: 1,1,1-Triethoxyethane. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Sun, HY; Wu, GM; Xie, XG or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Sroda-Pomianek, K; Palko-Labuz, A; Pola, A; Ferens-Sieczkowska, M; Wesolowska, O; Koziol, A in [Sroda-Pomianek, Kamila; Palko-Labuz, Anna; Pola, Andrzej; Wesolowska, Olga] Wroclaw Med Univ, Dept Biophys & Neurobiol, Ul Chalubinskiego 3, PL-50368 Wroclaw, Poland; [Ferens-Sieczkowska, Miroslawa; Koziol, Agata] Wroclaw Med Univ, Dept Chem & Immunochem, Ul M Sklodowskiej Curie 48-50, PL-50369 Wroclaw, Poland published TMPE Derived from Saffron Natural Monoterpene as Cytotoxic and Multidrug Resistance Reversing Agent in Colon Cancer Cells in 2020.0, Cited 52.0. Name: 1,1,1-Triethoxyethane. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

Terpenes constitute one of the largest groups of natural products. They exhibit a wide range of biological activities including antioxidant, anticancer, and drug resistance modulating properties. Saffron extract and its terpene constituents have been demonstrated to be cytotoxic against various types of cancer cells, including breast, liver, lung, pancreatic, and colorectal cancer. In the present work, we have studied anticancer properties of TMPE, a newly synthesized monoterpene derivative of beta-cyclocitral-the main volatile produced by the stigmas of unripe crocuses. TMPE presented selective cytotoxic activity to doxorubicin-resistant colon cancer cells and was identified to be an effective MDR modulator in doxorubicin-resistant cancer cells. Synergy between this derivative and doxorubicin was observed. Most probably, TMPE inhibited transport activity of ABCB1 protein without affecting its expression level. Analysis of TMPE physicochemical parameters suggested it was not likely to be transported by ABCB1. Molecular modeling showed TMPE being more reactive molecule than the parental compound-beta-cyclocitral. Analysis of electrostatic potential maps of both compounds prompted us to hypothesize that reduced reactivity as well as susceptibility to electrophilic attack were related to the lower general toxicity of beta-cyclocitral. All of the above pointed to TMPE as an interesting candidate molecule for MDR reversal in cancer cells.

Name: 1,1,1-Triethoxyethane. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Sroda-Pomianek, K; Palko-Labuz, A; Pola, A; Ferens-Sieczkowska, M; Wesolowska, O; Koziol, A or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com